In 1820, a very unique man named Martin Fugate immigrated to the United States from France. So one of Martin and Elizabeth’s sons, Zachariah, married Elizabeth’s sister (Yes, you read that correctly. The bluest of the bunch was Luna, and she lived a healthy life, bearing 13 children before she died at the age of 84. See more ideas about kentucky, blue, appalachia. But for the members of the Fugate clan, it was all too real. He married Elizabeth Smith, who also carried the recessive gene. There were only four other families besides the Fugates: Combes, Stacy, Ritchie, and Smith. Of their seven children, four were reported to be blue. I don’t think MOST people would stink if they took a shower, say, every other day. The area code for Cussy is 14214 (also known as code INSEE), and the Cussy zip code is 14400. Despite having this incredibly different skin color, they were physically just as healthy as anyone else, if not better. Scientists say that multiple generations of inbreeding resulted in a genetic condition that caused them to be born with blue skin. Normally diaphorase converts methemoglobin back to hemoglobin. More families were found -- Luke Combs, and Patrick and Rachel Ritchie, who were "bluer'n hell" and embarrassed by their skin color. Over 59 different items from Gifts. Two conditions cause people to live and be (literally) blue. Some of the pink-skinned family members moved away in the 1900’s, but for those who stayed within their comfort zone of Troublesome Creek, it only forced them to continue picking someone to marry from one of the four families. Because these blue veins were only seen at the nobles and upper-class people of Spain, people started to refer to them as “blue bloods”. At an American Heart Association clinic in the town of Hazard, Cawein found a nurse, Ruth Pendergrass, and she was willing to assist. To get the disorder, a person would have to inherit two genes -- one from each parent. She was a sister to one of the Fugate women.". Later in 1965 he was famous for another reason. In methemoglobinemia, the hemoglobin is unable to carry oxygen and it also makes it difficult for unaffected hemoglobin to release oxygen effectively to body tissues. By the time reports appeared in the media on the disorder, the Stacy family was upset with insinuations about in-breeding that fed into stereotypes of backwoods Appalachia. I do have a thought for you, or thoughts. They get their nickname from the blue robes they wear. Now, let’s see what else we have on our list of… Dr. E. M. Scott, who worked in public health at the Arctic Research Center in Anchorage, had seen a recessive genetic trait among Alaskans that turned their skin blue. At that time, the group of people who took advantage of the land grants and founded the village of Troublesome Creek was incredibly small. Even though they were from different countries, and the odds were probably a billion-to-one, they both carried the recessive gene for an extremely rare condition known as Methemoglobinemia. As coal mining arrived in Kentucky in 1912 and the Fugates moved outside of Troublesome Creek, the blue people began to disappear. Medical breakthrough saves girls with rare debilitating disease. Scott speculated these people lacked the enzyme diaphorase in their red blood cells. "That was the pain of being blue in a world that is mostly shades of white to black. One of Martin and Elizabeth Fugate's blue boys, Zachariah, married his mother's sister. "It also exemplifies the intersection between disease and society, and the danger of misinformation and stigmatization.". Very few people knew they even existed, until today. Cawein and Pendergrass began to ask questions -- "Do you have any relatives who are blue?" I just knew that patient was going to die right there in the health department, but she wasn't a'tall alarmed. The Fugates married other Fugate cousins and families who lived nearby, with names like Combs, Smith, Ritchie and Stacy. In 1960, he decided to move near Troublesome Creek in the hopes to meet one … The Fugate progeny had a genetic condition called methemoglobinemia, which was passed down through a recessive gene and blossomed through intermarriage. French people are often portrayed wearing a navy and white striped shirt, a beret, a baguette under their arm, and a cigarette in their mouth. ABCNews.com was unable to determine if Benjamin Stacy is still alive -- he would be 37 today. Mar 14, 2017 - Explore Carol Kline's board "Blue Fugates of Kentucky", followed by 227 people on Pinterest. People with gray eyes have irises that do not contain any melanin, and also extra amounts of collagen in a part of the eye called the stroma. The color of their skin was so shocking for normal people to see, that they chose to stay hidden away from the rest of society in their small community. Unbeknownst to the couple, they were coincidentally both carriers of a recessive gene (met-H) that caused methemoglobinemia, which can tint the skin of sufferers blue. "If I carry a bad recessive gene with a rare abnormality and married, the child probably wouldn't be sick, because it's very rare to meet another person with the [same] bad gene and the most frequent cause therefore is in-breeding," Tefferi said. The genetic form of methemoglobinemia is caused by one of several genetic defects, according to Tefferi. Deep in the woods of Kentucky, a fiercely private family gave birth to blue-skinned children since the 1800s. He married a red-haired American named Elizabeth Smith with a very pale complexion. "You almost never see a patient with it today," he said. But at levels of between 10 and 20 percent a person can develop blue skin without any other symptoms. Martin Fugate came to Troublesome Creek (near Hazard) from France in 1820 and… well… he happened to be blue. Once he was in Kentucky, he met and married a red haired woman named Elizabeth Smith. Most of blue Fugates never suffered any health effects and lived into their 80s and 90s. Normally, Methemoglobinemia is so rare, that this condition would no longer show up in the children of the next generation. "Her face and her fingernails were almost indigo blue," she told Trost. We specialize in stain resistant coated tablecloths and French tea towels. The Fugates probably had a deficiency in the enzyme called cytochrome-b5 methemoglobin reductase, which is responsible for recessive congenital methemoglobinemia. "It's a disease that one learns about in medical school and it is infrequent enough to be on every exam in hematology.". Stacy is the great-great-great-great-grandson of Martin Fugate and Elizabeth Smith – but by this point, the blue people of Kentucky are just a memory. In 1665, the French crown ordered a group of French soldiers to reinforce New France and protect its investments there. The predisposition to be born with the genetic disorder kept passing on to each new generation. -- and mapped a family tree and took blood samples. One of their sons, Levy, married a Ritchie girl and had eight children, one of them Luna. Even those who looked normal were carriers of the recessive gene that caused the disorder. Since there was not a huge variety in the gene pool, there was a lot of inbreeding going on, with people marrying their first and second cousins. Feb. 22, 2012— -- Benjamin "Benjy" Stacy so frightened maternity doctors with the color of his skin -- "as Blue as Lake Louise" -- that he was rushed just hours after his birth in 1975 to University of Kentucky Medical Center. The most detailed account, "Blue People of Troublesome Creek," was published in 1982 by the University of Indiana's Cathy Trost. He wanted to settle down for a new life in Troublesome Creek, Kentucky, because the United States offered free land to people willing to settle down there. He married a Kentuckian named Elizabeth Smith, who also carried the blue gene, so to speak. Symptoms may include headache, dizziness, shortness of breath, nausea, poor muscle coordination, and blue-colored skin (cyanosis). Person in Michigan wins Mega Millions' $1 billion jackpot, 2nd-largest total ever, For GOP firebrand Rep. Lauren Boebert, anger and suspicion linger after Capitol riot, Several storms to move across US, hazardous weather expected coast to coast. Originally their clothing was deeply dyed with natural indigo.

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